New progress of novel targets for iron overload in the 56th American Society of Hematology annual meeting
10.3760/cma.j.issn.1009-9921.2015.04.006
- VernacularTitle:铁过载治疗的新靶点:第56届美国血液学会年会报道
- Author:
Xudong TANG
;
Lu ZHANG
;
Feng LIU
- Publication Type:Journal Article
- Keywords:
Iron overload;
Novel targets;
American Society of Hematology annual meeting
- From:
Journal of Leukemia & Lymphoma
2015;24(4):211-213
- CountryChina
- Language:Chinese
-
Abstract:
New progress of guidelines for novel targets to iron overload in the 56th American Society of Hematology (ASH) annual meeting was reviewed.β-thalassemia and hereditary hemochromatosis disorders,and inappropriately low levels of the liver hormone hepcidin are responsible for the increased iron absorption,leading to toxic iron accumulation in many organs.Several studies have shown that targeting iron absorption could be beneficial to reducing or preventing iron overload in these 2 disorders.New approaches target Tmprss6.Additional strategies in β-thalassemia are showing beneficial effects in ameliorating ineffective erythropoiesis and anemia.The goal of this review is to discuss the major factors controlling iron metabolism and erythropoiesis and to discuss potential novel therapeutic approaches to reduce or prevent iron overload in these 2 disorders and ameliorate anemia in β-thalassemia.
