Study of CD4+ CD25+Foxp3+ regulatory T cells in peripheral blood of non-small-cell lung cancer patients
10.3760/cma.j.issn.1008-6706.2015.04.011
- VernacularTitle:非小细胞肺癌患者外周血CD4+ CD25+ Foxp3+调节性T细胞的研究
- Author:
Jing GUO
;
Zhongda LIU
;
Zunjing ZHANG
- Publication Type:Journal Article
- Keywords:
T-Lymphocytes;
Carcinoma,Non-small-cell lung;
Flow cytometry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(4):510-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the level of CD4+ CD25+ Foxp3+ regulatory T cells in peripheral blood of non-small-cell lung cancer patients.Methods The ratio of CD4+ CD25+ Foxp3+ T cells inperipheral blood of lung cancer group and control group were determined by flow cytometry.Its clinic significance was analyzed,Results The ratio of CD4+ CD25+ Foxp3+ Treg cells [the ratio of CD4+ CD25+ T and CD4+ CD25+ Foxp3+ T cells were (14.42 ± 1.22) ％ and (5.34 ± 0.45) ％] inperipheral blood was higher in the non-small-cell lung cancer group than in control group [the ratio of CD4+ CD25+T and CD4+ CD25+Foxp3+ T cells were (10.67 ±0.98)％ and (3.98 ±0.68)％] (t =2.431,2.273,all P ＜ 0.05).It was also higher in adenocarcinoma [CD4+ CD25+ T/CD4+ T to (15.05 ± 0.92) ％,CD4+ CD25+ Foxp3+ T/CD4+ T to (5.99 ± 0.38) ％] than squamous carcinoma [CD4+ CD25+ T/CD4+ T to (13.03 ± 1.64) ％,CD4+ CD25+ Foxp3+ T/CD4+ T to (3.91 ± 0.62) ％] (t =2.264,2.109,all P ＜ 0.05),and stage IV higher than stage m (t =2.165,2.058,all P ＜ 0.05).Conclusion The level of CD4+ CD25+ Foxp3+ Treg cells in peripheral blood of non-small cell lung cancer was significantly higher than that of healthy subjects,related with the pathological type and clinical stage.The CD4+ CD25+ Foxp3+ Treg cells may participate in the occurrence and development of non-small cell lung cancer.
