The relationship between circadian clock gene Per2 and VEGF, cyclin D1 expression in esophageal cancer
10.3760/cma.j.issn.1008-6706.2015.03.011
- VernacularTitle:食管癌组织中生物钟基因Per2的表达及其与血管内皮生长因子、细胞周期蛋白D1的相关性
- Author:
Zhifeng HE
;
Chuang CHI
;
Xiang ZHANG
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
Clock gene;
VEGF
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(3):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of circadian clock gene Per2 in the tissue of esophageal cancer and the relevance between VEGF,cyclin D1.Methods 80 cases with esophageal cancer who received surgical treatment and pathological specimens preserved were selected,and the normal tissues adjacent to carcinoma were used as control.The expression of Per2,VEGF and cyclin D1 were detected by immunohistochemistry,and the data were analyzed.Results Compared the tissue adjacent to carcinoma with carcinoma tissue,Per2,VEGF and cyclin D1 expression had statistically significant differences(x2 =26.86,24.34,23.72,all P ＜0.01).Per2 expression in different differentiation degree and the TMN stages had statistically significant differences (x2 =6.45,7.77,all P ＜ 0.05) ;cyclin D1 expression in lymph node metastasis and TMN stages had statistically significant differences(x2 =12.99,8.99,all P ＜ 0.01) ;VEGF expression in lymph node metastasis and TMN stages had statistically significant differences(x2 =6.68,6.14,all P ＜ 0.01).Per2 expression was negatively correlated with VEGF,cyclin D1 expression (r =-0.644,-0.523,all P ＜ 0.01).Conclusion Clock gene Per2 and VEGF,cyclin D1 expression in esophageal cancer has certain correlation,it can be a prognostic indicator of esophageal cancer.
