Effect of calcitriol combined with losartan on diabetic nephropathy and influence on pulse wave velocity and ankle brachial index
10.3760/cma.j.issn.1008-6706.2015.04.019
- VernacularTitle:骨化三醇联合氯沙坦治疗糖尿病肾病疗效观察及对脉搏波传导速度和踝臂指数的影响
- Author:
Jingjing ZHANG
;
Xiuyan WANG
;
Li HAO
;
Yuan CHENG
- Publication Type:Journal Article
- Keywords:
Diabetic Nephropathy;
Calcitriol;
Losartan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(4):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of calcitriol combined with losartan on diabetic nephropathy in grade Ⅲ and early Ⅳ.Methods 47 patients with diabetic nephropathy were enrolled.Patients were randomly assigned to receive losartan or both losartan and calcitriol according to randomized table for 6 months.At baseline time and after 6 months,the 24-hour urinary protein excretion,estimated glomerular filtration rate (eGFR),serum creatinine(SCr),blood pressure,fasting blood-glucose,serum calcium,serum phosphorus,pulse wave velocity(PWV) and ankle brachial index(ABI) were measured.Results The urinary protein excretion showed that there was significant decrease in the mix-treated group[(824.81 ± 307.84) g/24h vs (390.75 ± 173.51) g/24h,t =10.51,P ＜ 0.01] and the control group [(860.64 ± 313.89) g/24h vs (676.16 ± 297.71)g/24h,t =6.91,P ＜ 0.01].Furthermore,the mix-treated group had the lower proteinuria compared the group given losartan only(t =2.56,P =0.015).No significant differences were observed decrease in estimated eGFR and change in serum calcium,serum phosphorus,PWV and ABI between the two groups.Conclusion Addition of calcitriol to a renin-angiotensin system inhibitor resulted in a safe decrease in proteinuria in patients with diabetic nephropathy.
