Progress of guidelines for quantifying iron overload: reports from the 56th American Society of Hematology annual meeting
10.3760/cma.j.issn.1009-9921.2015.02.005
- VernacularTitle:铁过载量化计算指南:第56届美国血液学会年会报道
- Author:
Xudong TANG
;
Lu ZHANG
;
Feng LIU
- Publication Type:Journal Article
- Keywords:
Iron overload;
Quantifying;
American Society of Hematology annual meeting
- From:
Journal of Leukemia & Lymphoma
2015;24(2):85-87
- CountryChina
- Language:Chinese
-
Abstract:
Progress of guidelines for quantifying iron overload in the 56th American Society of Hematology (ASH) annual meetings was reviewed.This article reviewed the use of historical data,serological measures,and MRI to estimate somatic iron burden.Before chelation therapy utilization,transfusional volume was an accurate method for estimating liver iron burden,whereas transferrin saturation reflected the risk of extrahepatic iron deposition.Liver biopsy was invasive and plagued by sampling variability.In the current study,we recommended annual liver iron concentration to be measured by MRI for all patients on chronic transfusion therapy.And it was important to measure cardiac T2* by MRI every 6-24 months depending on the clinical risk of cardiac iron deposition.Recent validation data for pancreas and pituitary iron assessments was also presented,while the further confirmatory data was suggested before these techniques could be recommended for routine clinical use.
