Toxicity of dose-adjusted BEACOP regimen in the treatment of lymphoma
10.3760/cma.j.issn.1009-9921.2015.01.018
- VernacularTitle:剂量调整的BEACOP方案治疗淋巴瘤不良反应分析
- Author:
Yifan PANG
;
Fei DONG
;
Jing WANG
;
Ping YANG
;
Hongmei JING
;
Jijun WANG
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Antineoplastic combined chemotherapy protocols;
Toxicity
- From:
Journal of Leukemia & Lymphoma
2015;24(1):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the toxicity of dose adjusted-BEACOP (DA-BEACOP,classic CHOP regimen plus etoposide and (or) bleomycin with or without rituximab) regimen for poor-prognosis lymphoma.Methods 89 patients with poor-prognosis lymphoma who had been treated in-patient at Peking University Third Hospital during August 2002 and February 2012 were retrospectively studied.All patients received at least 1 cycle of DA-BEACOP regimen.Results 3-4 grade adverse events were observed in 74 (83.1％) patients,most of which was myelosuppression (73 cases,82.0 ％).There was not death related with the treatment.Compared to male patients,female patients suffered higher rates of grade 3-4 of toxicity (94.2 ％,33/35 vs 75.9 ％,41/54) (P =0.024).The rate of grade 3-4 of hematological toxicity in patients who were pretreated with ≥3 cycles of chemotherapy than that in patients receiving≤2 cycles of chemotherapy (95.9 ％,47/49 vs 75.0 ％,30/40) (P =0.004),while the rate of 3-4 hematological toxicity in pret-radiotherapy posed patients was higher than that in their counterparts who did not receive radiotherapy (95.9 ％,47/49 vs 75.0 ％,30/40) (P =0.022).Conclusion The DA-BEACOP regimen showed manageable toxicity in patients with poor-prognosis lymphoma.
