Clinical and laboratory investigation of hematological malignancies with t(11;19)(q23;p13.1)
10.3760/cma.j.issn.1009-9921.2015.01.017
- VernacularTitle:伴t(11;19)(q23;p13.1)恶性血液病的临床和实验室特征
- Author:
Li TAN
;
Xin LIU
;
Jincai ZENG
;
Shaojiang YANG
;
Xiaohong WU
- Publication Type:Journal Article
- Keywords:
Chromosome;
Translocation;
Cytogenetics;
Hematological malignancies
- From:
Journal of Leukemia & Lymphoma
2015;24(1):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and laboratory characteristics of hematological malignancies with t(1 1;19)(q23;p13.1).Methods Chromosome specimens of bone marrow cell from a patient with hematological malignancy were collected.After short-term culture,and chromosome karyotype analysis was carried out by R banding technique.Results The chromosome karyotype of the patient diagnosed with AML M4+ was t (11;19)(q23;p13.1).The patient did not obtain complete remission after application of MA regimen chemotherapy.Conclusions t(11;19)(q23;p13.1) translocation is a rare and recurring chromosome abnormality,which is related with a specific type of AML.The prognosis of the AML patients with this chromosome abnormality is poor.
