The preventive effect of hyaluronic acid on post-surgical pelvic and abdominal adhesion

VernacularTitle:透明质酸钠凝胶在腹、盆腔术后粘连预防中的应用
Author: Danhong HU ; Fang LIU
Publication Type:Journal Article
Keywords: Adhesions; Hyaluronic acid
From: Chinese Journal of Primary Medicine and Pharmacy 2015;22(3):332-333
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical effect of sodium hyaluronic acid on prevention of post-surgical pelvic and abdominal adhesion in gynecology.Methods 336 patients with pelvic and abdominal operation,using the double blind method for the patients and doctors,were randomly divided into the observation group (172 cases)and control group(164 cases).The experimental group was given hyaluronic acid in corresponding regions of the peritoneum,and the control group was not given any tissue adhesion prevention measures.Postoperative adhesions incidence and the change of serum CRP level of two groups were recorded.Results There was significant difference between the two groups in postoperative adhesions incidence (47.5％ vs 19.8％,x2 =13.10,P ＜ 0.01).The CRP level of the observation group changed significantly as compared with the control group after operation [(24.5 ±3.4)mg/L vs(12.7 ±3.9)mg/L(t =20.86,P＜0.01)].Conclusion Hyaluronic acid in prevention of postoperative adhesion of pelvic and abdominal operation is effective on improving the serum level of inflammatory factors.