Effect of early application of naloxone on serum hs-CRP and S100B protein in neonates with hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1008-6706.2015.02.005
- VernacularTitle:早期应用纳洛酮对新生儿缺氧缺血性脑病患儿血清超敏C反应蛋白和S100B蛋白的影响
- Author:
Jinghui DU
- Publication Type:Journal Article
- Keywords:
Naloxone;
Brain injury,chronic;
C-reactive protein;
Calcium-binding proteins
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(2):172-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of early application of naloxone on serum high sensitivity C-reactive protein(hs-CRP) and S100B protein in neonates with hypoxic-ischemic encephalopathy.Methods According to the digital table,86 neonates with hypoxic-ischemic encephalopathy were randomly divided into the control group (n =43 cases) and the observation group (n =43 cases).The control group was treated by conventional therapy,while the observation group was treated by conventional therapy plus naloxone.They were treated for 7-10 days.The clinical effect was evaluated.Serum hs-CRP and S100B protein were detected before and after treatment.Results The total effective rate of the control group was 86.0％,which was significantly lower than 97.7％ of the observation group (x2 =5.78,P ＜ 0.05).The sense of recovery,reflecting the recovery and muscle tension recovery time of the observation group were less than those in the control group (t =5.017 2,3.991 6,2.904 8,all P ＜ 0.05).After treatment,the sertum hs-CRP and S100B protein in the two groups were significantly decreased (t =6.776 2,10.903 8,7.772 8,11.092 6,all P ＜ 0.01),compared with the control group,the decrease of the observation group was more significant (t =3.368 2,3.092 8,all P ＜ 0.05).Conclusion Early application of naloxone in neonates with hypoxic-ischemic encephalopathy can decrease serum hs-CRP and S100B protein.
