Clinical observation of nedaplatin combined with Gimeracil and oteracil porassium capsules or gemcitabine in the treatment of patients with distant metastatic nasopharyngeal carcinoma
10.3760/cma.j.issn.1008-6706.2015.01.004
- VernacularTitle:奈达铂联合替吉奥治疗晚期转移性鼻咽癌临床观察
- Author:
Yan ZOU
- Publication Type:Journal Article
- Keywords:
nasopharyngeal;
metastasis;
gimeracil and oteracil porassium capsules;
nedaplatin;
gemcitabine;
efficacy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of gimeracil and oteracil porassium capsules combined with nedaplatin in the treatment of the patients with distant metastatic nasopharyngeal carcinoma.Methods Fourty cases were randomly divided into the observation group and control group by random digital table.19 cases in the observation group were treated with oteracil potassium capsules combined with nedaplatin.21cases in the observation group were treated with gemcitabine combined with nedaplatin.The response rate,response rate(RR) and progression free survival(PFS),toxicity were evaluated according to response evaluation criteria in solid tumors (RECIST).Results The response rate were 52.6％,52.3％ respectively,the median progression-free survival were 5.5 and 5.2 months,respectively.Grade Ⅲ an Ⅳ platelet supression were 10.5％,38.0％ between the observation group and control group.It was statistically significant between the two group(x2 =4.89,P ＜ 0.05).Conclusion Oteracil porassium capsules combined with nedaplatin is similar with gemcitabine combined with nedaplatin in the distant metastatic nasopharyngeal carcinoma,the adverse reaction was lighter than that of the control group.
