Immunomodulatory property of Compound Shougong powder on S180 tumor bearing mice
10.3760/cma.j.issn.1008-6706.2015.01.003
- VernacularTitle:复方守宫散对S180荷瘤小鼠免疫功能的影响
- Author:
Jian WU
;
Jiarong GAO
;
Yanquan HAN
;
Huan LUO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Mice;
Compound Shougong powder;
Humoral immunity;
Cellular immunity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;22(1):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunomodulatory property of Compound Shougong powder(SGS) on S180 tumor-bearing mice.Methods The S180 model of tumor-bearing mice by Kunming mice were prepared.Then,the tumor-bearing mice were randomized into the model group,positive control group,and SGS groups (29.25g/kg,19.50g/kg,9.75g/kg).Besides the normal group,the other groups were used intragastric administration of into tumor-bearing mice by one time,14 consecutive days.The carbon clearance,quantitative hemolysis and DNFB induced delayed-type hypersensitivity were applied to assay effects of SGS on nonspecific immunity,humoral immunity and cellular immunity.Results Compared with the model control group,in the SGS groups,the tumor-bearing mice with spleen and thymus index of organ improved (all P ＜ 0.05),and the clearance index and values of phagocytic index were elevated(all P ＜0.05),and the productions of IgM and IgG in serum and hemolysin in splenocytes were enhanced(all P ＜0.05),and the percentages of T cells expressing CD4+,CD8+ and the ratio of two subset of T lymphocyte increased,and the IL-2 production of spleen lymphocytes was also improved (all P ＜ 0.05).Conclusion SGS showed significant immunomodulatory property on tumor-bearing mice through specific and nonspecific immunity.
