A study on clinical characteristics for T-cell acute lymphoblastic leukemia with SIL-TAL1 fusion gene

VernacularTitle:伴有SIL-TAL1融合基因的急性T淋巴细胞白血病临床特征研究
Author: Guangrong ZHU ; Na WANG ; Lijun JIANG ; Jianmin JI ; Qun SHEN ; Hanying SUN
Publication Type:Journal Article
Keywords: Acute T cell lymphoblastic leukemia; SIL-TAL1 gene rearrangement; Acute tumorlysis syndrome; Disseminated intravascular coagulation; Prognosis
From: Journal of Leukemia & Lymphoma 2014;23(12):712-716
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical characteristics and outcome of T-cell acute lymphoblastic leukemia (T-ALL) with SIL-TAL1 rearrangement.Methods 62 newly diagnosed T-ALL patients including 15 patients with SIL-TAL1 rearrangement were systemically reviewed.Results Compared with SIL-TAL1-T-ALL patients,SIL-TAL1 + T-ALL patients was characterized by higher white blood cell count (P =0.029) at diagnosis,predominant cortical T-ALL immunophenotype (P =0.028) of the leukemic blasts,a higher prevalence of acute tumor lysis syndrome (P ＜ 0.001) and disseminated intravascular coagulation (P ＜ 0.001),which led to a higher early mortality (26.7 ％ (4/15) vs 4.3 ％ (2/47),P =0.011).Compared with SIL-TAL1-patients,SIL-TAL1+ patients had shorter relapse free survival (2 months vs 12 months,P =0.007) and overall survival (4 months vs 25 months,P =0.002).Conclusion SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.