Model organism C.elegans applications in the complex-system drug activity evaluation
10/3969.j.issn.1671.7856.2015.003.13
- VernacularTitle:模式生物线虫在药物复杂体系活性评价中的应用
- Author:
Xinpei WANG
;
Xuan YU
;
Fan LEI
;
Dongming XING
;
Lijun DU
- Publication Type:Journal Article
- Keywords:
Caenorhabditis elegans;
Model organism;
Drug innovation;
Chinese herb
- From:
Chinese Journal of Comparative Medicine
2015;(3):67-72
- CountryChina
- Language:Chinese
-
Abstract:
Caenorhabditis elegans (C.elegans), has developed into an useful model for biomedical research, particularly in the targets of novel drugs and the related mechanism.C.elegans, combining with cost-effective cultivation, simple biological structure, make for high-throughput screenings in vivo model.In this review, we explore the feasibility of C.elegans in drug activity evaluation of complex systems.Because of the body independence of C.elegans, it provided good platform for the efficacy and mechanism of research on new drugs as well as Chinese herbal extract in vivo, showing a good prospect.
