Decreased interhemispheric resting-state functional connectivity in chronic primary trigeminal neuralgia
10.3969/j.issn.1002-1671.2015.04.001
- VernacularTitle:慢性原发性三叉神经痛患者静息态镜像同伦功能连接研究
- Author:
Mingyue MA
;
Yufeng LIU
;
Lei GAO
;
Yuan WANG
;
Xiaoping WU
;
Xiaohui YIN
;
Yanjun GAO
;
Junle YANG
- Publication Type:Journal Article
- Keywords:
primary trigeminal neuralgia;
resting-state functional magnetic resonance imaging;
voxel-mirrored homotopic con-nectivity
- From:
Journal of Practical Radiology
2015;(4):525-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the alterations of interhemispheric resting-state functional connectivity in patients with chro-nic primary trigeminal neuralgia (CPTN).Methods Twenty patients with CPTN and 20 age-,gender-,and education-matched healthy subjects underwent a resting-state functional magnetic resonance imaging (rs-fMRI)scanning.The voxel-mirrored homo-topic connectivity(VMHC)approach and statistic analysis were used to investigate the interhemispheric coordination of the whole brain.Results Compared with healthy controls,decreased VMHC was found in patients with CPTN,including medial and lateral or-bitofrontal cortex,and premotor (P <0.05,GRF corrected).Conclusion Our results suggest that decreased VMHC in brain regions indicate the aberrant perceptual and affective processing of CPTN,and limited complex movements function.
