Association between gene polymorphism ofBLK gene and clinical characteristic in Kawasaki disease
10.3969/j.issn.1000-3606.2015.04.013
- VernacularTitle:BLK基因多态性与川崎病及其临床特点的相关性
- Author:
Qizhong DONG
;
Chao ZHANG
;
Yueru LI
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
BLK gene;
clinical characteristic
- From:
Journal of Clinical Pediatrics
2015;(4):342-344
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association of two single nucleotide polymorphisms (SNPs) (rs2736340 and rs2618476) inBLK gene with Kawasaki disease (KD) and coronary artery lesion in Chinese Han children.MethodsIn the case-control study, 179 children with KD were selected and 182 healthy check-up children during the same period were selected as normal controls. The genotypes of two SNPs inBLK gene were detected using PCR-RFLP and the data were analyzed. ResultsThere was no difference in distribution of three genotypes (TT, CT, and CC) of SNP rs2736340 between KD group and control group (P=0.093). However, T allele frequency in KD group was signiifcantly higher than that in control group (P=0.021). The distribution of three genotypes (CC, CT, and TT) of SNP rs2618476 between KD group and control group was signiifcantly different (P=0.021). C allele frequency in KD group was signiifcantly higher than that in control group (P=0.006). The two SNPs inBLK gene were not associated with rash, hand-foot edema and coronary artery lesion (CAL), but SNP (rs2618476) was asso-ciated with oral mucosa lesions (P=0.018).ConclusionsThe SNP (rs2736340) inBLK gene was not associated with KD, but the T-allele was associated with KD. The SNP (rs2618476) was associated with KD in Han Chinese, and was also associated with oral mucosa lesions in KD patients.
