Advances in antiradiation drugs
10.7644/j.issn.1674-9960.2015.06.013
- VernacularTitle:抗辐射药物研发进展
- Author:
Kunping WANG
;
Yong XU
;
Changyan LI
- Publication Type:Journal Article
- Keywords:
radiation-protective agents;
antiradiation drugs;
radiation injuries;
mechanism;
amifostine
- From:
Military Medical Sciences
2015;(6):464-467
- CountryChina
- Language:Chinese
-
Abstract:
Antiradiation drugs, also known as radioprotective agents, can prevent humans from radiation injury,reduce the clinical symptoms of radiation sickness,promote early recovery and reduce morbidity or mortality.Early developments of such agents focused on thiol synthetic compounds, such as amifostine (WR 2721).This compound reduced mortality, but its disadvantages, such as large use and high toxicity, limited its use in clinical practice.To find a suitable radioprotective agent is crucial to reducing side effects induced by ionizing radiation and increasing survival rate in patients during radiotherapy.In this paper, the classification and mechanism of radioprotective agents are reviewed and future developments in this field are predicted.
