Distribution and drug resistance change of bacteria isolated from cerebro-spinal fluid of neurosurgery patients
10.3969/j.issn.1671-9638.2015.03.003
- VernacularTitle:神经外科患者脑脊液病原菌分布及耐药性变迁
- Author:
Qian LI
;
Yuanxing WU
;
Mingzhong TANG
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
neurosurgery;
intracranial infection;
cerebrospinal fluid;
pathogen;
drug resistance,microbial;
anti-microbial agent
- From:
Chinese Journal of Infection Control
2015;(3):159-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the isolation and drug resistance change trend of pathogens isolated from ce-rebrospinal fluid (CSF)of neurosurgical patients in Beijing Tian Tan Hospital.Methods Pathogens and antimicro-bial susceptibility of pathogens from CSF specimens of neurosurgical patients from August 1997 to August 2013 were analyzed.Results A total of 2 732 isolates of pathogens were detected,gram-positive and gram-negative bacte-ria accounted for 71 .23% (n = 1 946 )and 28.77% (n =786 )respectively.The top three isolated bacteria were Staphylococcus spp .(n =1 751 ,64.09%),Acinetobacter spp .(n =254,9.30%),and Enterococcus spp .(n =172,6.30%).Gram-positive bacteria were the major isolated pathogens,detection rate of methicillin-resistant Staphylococcus aureus (MRSA ) and methicillin-resistant coagulase-negative Staphylococcus (MRCNS ) was 74.34% and 80.73% respectively;gram-negative bacteria increased gradually in recent years.All Staphylococcus spp .isolates were highly sensitive to vancomycin and linezolid(>90%).The overall antimicrobial susceptibility rate of gram-negative bacteria decreased,susceptibility rates of Acinetobacter spp .to imipenem and meropenem was 51 % and 44% respectively.Conclusion The major pathogens causing intracranial infection in neurosurgical patients are gram-positive bacteria,the detection rates of MRSA and MRCNS are high;gram-negative bacteria,especially extensively drug-resistant Acinetobacter spp .shows an increasing tendency in recent years.
