Effects of Donepezil on cognitive function of delayed encephalophthy after acute carbon monoxide poisoning
- VernacularTitle:多奈哌齐对急性一氧化碳中毒迟发性脑病患者认知功能的影响
- Author:
Haibo XU
;
Qi ZHAO
- Publication Type:Journal Article
- Keywords:
Donepezil;
carbon monoxide poisoning;
delyed encephalophthy
- From:
Journal of Clinical Neurology
2015;(2):134-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Donepezil on cognitive function of delyed ephalophthy after acute carbon monoxide poisoning ( DEACMP) .Methods Eighty patients with DEACMP were randomly divided into control group ( 40 cases ) and treatment group ( 40 cases ) .The control group was given treatment of regular medicine, placebo and hyperbaric oxygenation.The treatment group was given treatment of regular medicine, Donepezil and hyperbaric oxygenation.The dose of Donepezil was 5.0 mg per night, and 90 d was a period of treatment.The cognitive function of patients was evaluated respectively by MMSE and Barthel Index rating scale ( BI) .And the results were compared between the two groups.Results Compared with before treatment, the MMSE and BI scores of the two groups after treatment were significantly increased (P<0.05 -0.01).And after the treatment, the MMSE and BI scores of the treatment group were significantly higher than those in the control group (P<0.05-0.01).Conclusion Donepezil can greatly improve the cognitive function of DEACMP patients, it is worthy to be clinical promoted.
