The study of the correlation between diffusion tensor imaging and cognitive impairment in cerebral small vessel disease
10.3969/j.issn.1002-1671.2015.04.031
- VernacularTitle:脑小血管病的 DTI及其与认知障碍相关性的研究
- Author:
Liwen DAI
;
Hui LI
;
Chaolin JIN
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
diffusion tensor imaging;
fractional anisotropy;
apparent diffusion coefficient;
mont-perllier cognitive function scale
- From:
Journal of Practical Radiology
2015;(4):646-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of occult damage of cerebral white matter in patients with small vessel disease by using diffusion tensor imaging (DTI)technology,and its relationship with cognitive impairment.Methods Twenty-eight patients with CSVD and twenty-three matched volunteers all received T1 WI,T2 WI,DTI examination and montperllier cognitive function scale (MoCA).Then compare the difference between the two groups,and analysis the correlation between ADC and FA value of each re-gion of interested and MoCA score in CSVD group.Results ①FA values on bilateral frontal white matter in CSVD group were lower than control group,and ADC values were higher than control group,the difference was statistically significant (P <0.05 ).There were no significant differences in FA and ADC values on corpus callosum genu and splenium between two groups (P >0.05 );②In CSVD group,the FA value of bilateral frontal lobe white matter were positively correlated with the MoCA score (P <0.05 ),and the ADC value were negatively correlated with the MoCA score (P <0.05 ).there were no significantly correlations between FA and ADC values on corpus callosum genu and splenium and MoCA score (P >0.05 ).Conclusion Bilateral frontal white matter exist fi-ber occult damage in patients with CSVD,and the change of FA and ADC value can reflect the severity of cognitive impairment on a certain degree in patients with CSVD.
