Research progress of adenosine receptors in fibrosis diseases
10.3969/j.issn.1001-1978.2015.04.001
- VernacularTitle:腺苷受体在纤维化疾病发病中的作用研究进展
- Author:
Feng YANG
;
He WANG
;
Xiongwen LYU
;
Jun LI
- Publication Type:Journal Article
- Keywords:
adenosine;
adenosine receptors;
fibrosis diseases;
G protein-coupled receptors;
signaling pathways;
adenosine re-ceptor modulators
- From:
Chinese Pharmacological Bulletin
2015;(4):445-448
- CountryChina
- Language:Chinese
-
Abstract:
The fibrosis can occur in many kinds of organs,and its sustained progress may lead to organ structural damage and functional decline,and even the organ failure,which threatens the human health and the life seriously.Adenosine is an endogenous purine nucleoside that can be generated in various tissues of the body and regulate a multitude of body functions via the combina-tion with four different kinds of G protein-coupled receptors.Re-cent studies have found that adenosine receptors play an impor-tant role in regeneration tissue and fibrosis process.To under-stand the processes may be helpful to the treatment of fibrosis diseases.This review makes a summary on latest research pro-gress of adenosine receptors in fibrosis diseases.
