Inflammatory response and anti-inflammatory therapy after acute spinal cord injury
10.3969/j.issn.1001-1978.2015.04.003
- VernacularTitle:急性脊髓损伤后的炎症反应及其抗炎治疗
- Author:
Taoli WANG
;
Bing GU
;
Huanan LI
;
Guofu ZHANG
;
Si ZHANG
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
secondary damage;
inflammatory response;
anti-inflammatory therapy;
methylprednisolone;
minocy-cline
- From:
Chinese Pharmacological Bulletin
2015;(4):452-457
- CountryChina
- Language:Chinese
-
Abstract:
Acute spinal cord injury can lead to severe motor,sen-sory and sphincter muscle dysfunction.Inflammatory response caused by inflammatory cytokines plays a crucial role in the oc-currence and development of secondary damage.Maintaining the body balance between inflammaion and anti-inflammation through an appropriate anti-inflammatory intervention will be an important strategy for drug therapy of spinal cord injury.This paper mainly introduces the cause,process and participation of inflammatory response in the pathophysiological mechanism of acute spinal cord injury,and also reviews the latest progress of experimental research of anti-inflammatory drugs,aiming to provide reference for finding the safe and effective drugs.
