Role of tyrosine kinase of mast cell in allergy and its drug target
10.3969/j.issn.1001-1978.2015.04.006
- VernacularTitle:肥大细胞的酪氨酸激酶与抗过敏药物的分子靶向
- Author:
Fei QIAN
;
Tiantian ZHU
;
Shuang LING
;
Yiming LI
;
Jinwen XU
- Publication Type:Journal Article
- Keywords:
mast cell;
degranulation;
SFKs;
Fyn;
Lyn;
Syk;
SFKs inhibitor
- From:
Chinese Pharmacological Bulletin
2015;(4):465-469
- CountryChina
- Language:Chinese
-
Abstract:
The degranulation of mast cells represents a pivotal e-vent in the allergic disorders.The Src family kinases(SFKs)are as a starting signal in the activation of mast cell.Lyn,Fyn and Syk play important regulatory role in the degranulation of mast cells.Regulating SFKs can reduce the degranlation process and inhibit the allergic disorders.Therefore,SFKs inhibitors can be potential drugs in the allergy.It is necessary to study the targeted medicine of SFKs,which will be a new direction of drug develop-ment.
