Correlations of endoplasmic reticulum stress and cancer drug resistance
10.3969/j.issn.1001-1978.2015.04.005
- VernacularTitle:内质网应激与肿瘤细胞耐药的相关机制
- Author:
Yuanyuan YAN
;
Miao HE
;
Mingjie WEI
- Publication Type:Journal Article
- Keywords:
endoplasmic reticulum stress;
cancer drug resist-ance;
UPR;
ERS;
apoptotic suppression;
autophagy
- From:
Chinese Pharmacological Bulletin
2015;(4):461-464
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum is an important organelle in eu-karyotic cells.Endoplasmic reticulum stress (ERS)is usually triggered under cell hypoxia,carbohydrate undersupply or medi-cal treatment.Now,present studies show that ERS could activate several cell signal pathways and the UPR pathway is most widely researched.When UPR activates cell signal pathway,it can reg-ulate cancer drug resistance by involving with DNA damage re-pair,apoptotic suppression and autophagy.
