Pharmacological activation of serotonin 5-HT2C receptor ameliorates naloxone-precipitated withdrawal in morphine-dependent mice
10.3969/j.issn.1001-1978.2015.04.016
- VernacularTitle:5-羟色胺5-HT2C受体激动剂抑制吗啡依赖小鼠纳洛酮诱导的戒断行为
- Author:
Xian WU
;
Qin JIANG
;
Gang PANG
;
Huan LIU
;
Xinrong TAO
;
Liuyi DONG
;
Gongliang ZHANG
- Publication Type:Journal Article
- Keywords:
serotonin;
5-HT2C receptor;
morphine;
dependent;
naloxone;
withdrawal symptoms
- From:
Chinese Pharmacological Bulletin
2015;(4):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of pharmacolog-ical activation of serotonin 5-HT2C receptor (5-HT2C R) on naloxone-precipitated withdrawal in morphine-de-pendent mice. Method EthoVision Noldus video tracking system was used to record the effect of 5-HT2C R agonist WAY on locomotor activities and behavioral performances in mice.Results Selective 5-HT2C R ag-onist WAY (0.5,0.75 or 1 .0 mg·kg -1 ,i.p.)a-lone did not alter the locomotor activities as determined by distance traveled and velocity (all P values >0.05).Chronic morphine treatment induced depend-ence in mice as demonstrated by increases in distance traveled,velocity and jumping behavior.WAY (0.5, 0.75 or 1 .0 mg·kg -1 ,i.p.)and clonidine (0.2 mg ·kg -1 ,i.p.)significantly ameliorated naloxone-pre-cipitated withdrawal symptoms,including burrowing, jumping,body grooming,rearing,“wet dog”shakes, head shakes,face grooming,penile grooming,scratch (all P values <0.05).Conclusion Pharmacological activation of 5-HT2C R ameliorates naloxone-precipitated withdrawal symptoms in morphine-dependent mice.5-HT2C R may be a novel target to develop therapeutic ap-proach against morphine physical dependence,craving and relapsing.
