Basic fibroblast growth factor and fibrin glue in orthopedics
10.3969/j.issn.2095-4344.2015.12.024
- VernacularTitle:碱性成纤维细胞生长因子及纤维蛋白胶在骨科的运用
- Author:
Qi LI
;
Jian LI
- Publication Type:Journal Article
- Keywords:
Tissue Engineering;
Ligaments;
Fractures,Bone
- From:
Chinese Journal of Tissue Engineering Research
2015;(12):1931-1937
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Basic fibroblast growth factor can promote angiogenesis and connective tissue regeneration, but it can be degraded rapidly in vivo. Fibrin glue as a carrier can play a slow-release effect against the rapid degradation of basic fibroblast growth factor, so as to better play the biological role of basic fibroblast growth factor. But at present, the concrete application of them is stil in the research stage. OBJECTIVE:To review the research progress of the application of basic fibroblast growth factor and fibrin glue in orthopedics. METHODS:The recent literature concerning the application of basic fibroblast growth factor and fibrin glue in orthopedics was extensively reviewed by the first author through a computer-based retrieval of CNKI and Medline databases (2000-2014). RESULTS AND CONCLUSION:Finaly 64 articles were included in result analysis. Basic fibroblast growth factor can promote wound healing and tissue repair with the fibrin glue used as a carrier, but most studies are stil in the experimental stage and its clinical application needs further study.
