Stability of tissue engineering bone in the repair of bone defects：material degradation and bone formation
10.3969/j.issn.2095-4344.2015.12.025
- VernacularTitle:组织工程骨修复骨缺损的稳定性：材料降解与新骨形成
- Author:
Xiao ZHOU
;
Yufen QIAN
- Publication Type:Journal Article
- Keywords:
Tissue Engineering;
Stents;
Bone Transplantation
- From:
Chinese Journal of Tissue Engineering Research
2015;(12):1938-1942
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Scaffold materials are the important part of tissue engineering bone, and the ideal biodegradation speed of the scaffold materials can be in accordance with the regeneration speed of bone formation in order to achieve a long-term stability. OBJECTIVE:To summarize the biodegradability of different types of currently available scaffold materials and its relationship with bone formation. METHODS:The PubMed and CNKI database were searched by the first author using the key words of “tissue engineering bone, composite scaffold, scaffold degradation” in English and Chinese for articles addressing biodegradability of scaffold materials and its relationship with bone formation published during January 1996 and December 2013. RESULTS AND CONCLUSION:Many scaffold materials under organic, inorganic and organic-inorganic categories have been available and the current studies focus on inorganic materials and organic-inorganic composite materials.In vivo andin vitro studies indicate the different characteristics and relative merits of these scaffold materials. Organic materials have a relatively slow degradation rate while inorganic materials can completely degrade but have an insufficient mechanical property. For organic-inorganic composite materials, further studies are needed.
