ReIationships between sodium channeI NaV 1.7 and pain
10.3867/j.issn.1000-3002.2015.02.018
- VernacularTitle:钠通道 Nav1.7与疼痛关系的研究进展
- Author:
Xiaonan LLANG
;
Gang YU
;
Zhibing ZHENG
;
Ruibin SU
- Publication Type:Journal Article
- Keywords:
voltage-gated sodium channel;
NaV1.7;
pain;
analgesia
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(2):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Voltage-gated sodium channels (NaV1.1-NaV1.9) play important roles in the generation and maintenance of electrical excitability. NaV1.7 is preferentially expressed in peripheral somatic sensory neurons and sympathetic ganglion neurons. ln humans, gain-of-function mutations of SCN9A gene, which encodes NaV1.7, cause inherited neuropathic pain, whereas loss-of-function mutations result in a congenital indifference to pain without motor, cognitive and cardiac deficits. The effects of some analge-sics are associated, at least in part, with the NaV1.7 and selective NaV1.7 inhibitors have also been demonstrated to be analgesic in animal models. NaV1.7 has emerged as a potential target for the treat-ment of pain.
