Advances in roles of NF-κB in regulating pathways of apoptosis
10.3867/j.issn.1000-3002.2015.01.022
- VernacularTitle:NF-κB 在细胞凋亡中调节作用的研究进展
- Author:
Gaiyan REN
;
Aning SUN
;
Jingjing ZHANG
;
Chao DENG
;
Zhengtao WANG
;
Wei DOU
- Publication Type:Journal Article
- Keywords:
NF-κB;
apoptosis
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(2):323-327
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis is a process of programmed cell death that is controlled by genes. Normally, there are three regulation pathways involved in the process of apoptosis, including the signaling of intracel-lular mitochondria, endoplasmic reticula and extracellular death receptors. Recent studies showed that NF-κB is a key regulator in the process of apoptosis. NF-κB plays a promotional and a inhibitory role as well in the regulation of apoptosis, closely related to the the inhibitor of apoptosis proteins family, the B cell lymphoma/ lewkmia-2 family, tumor necrosis factor receptor associated factors, c-Jun N-terminal kinase, tumor necrosis factor related apoptosis inducing ligand and Fas-associated death domain protein-like interleukin-1β. Thus, investigation of the mechanism regarding NF-κB in apoptosis regulation is of great importance for apoptosis-related drug development. The paper reviews the recent research progress in the function of NF-κB in apoptosis pathway regulation.
