Hedgehog signaling pathway in chemocarcinogenesis and progression of breast cancer
10.3867/j.issn.1000-3002.2015.02.023
- VernacularTitle:Hedgehog 信号通路在乳腺癌化学致癌进展中的作用
- Author:
Dong CUL
;
Linqing YANG
;
Yun HE
;
Zhixiong ZHUANG
- Publication Type:Journal Article
- Keywords:
Hedgehog signaling pathway;
chemicals;
breast cancer
- From:
Chinese Journal of Pharmacology and Toxicology
2015;(2):328-332
- CountryChina
- Language:Chinese
-
Abstract:
The controversial results of several studies suggest that certain everyday-use chemicals may be linked to breast cancer. ln recent years, extensive researches have been carried out to under-stand breast carcinogenesis and the hedgehog(Hh) signaling pathway has emerged as a critical determi-nant of human breast cancer. Aberrant Hh signaling in adults results in carcinogenesis, angiogenesis, and metastasis. This review is focused on the Hh signaling pathway and chemicals in the regulation of breast cancer development and provide an updated survey of pre-clinical and clinical trials of novel strategies to target them.
