Clinical Significance of VEGF-C and COX-2 Expression in Gastric Carcinoma with Submucosal Invasion.
10.5230/jkgca.2009.9.3.96
- Author:
Yun Jung CHO
1
;
Jung Uee LEE
;
Kwan Ju LEE
;
Cho Hyun PARK
;
Seung Man PARK
;
Hae Myung JEON
;
Chang Joon AHN
;
Jeong Goo KIM
;
Dong Ho LEE
;
Sang Chul LEE
Author Information
1. Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. kalgs@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Early gastric cancer;
VEGF-C;
COX-2;
Lymph node metastasis
- MeSH:
Gastrectomy;
Humans;
Korea;
Lymph Node Excision;
Lymph Nodes;
Neoplasm Metastasis;
Prognosis;
Prostaglandin-Endoperoxide Synthases;
Stomach Neoplasms;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor C;
Vascular Endothelial Growth Factor D
- From:Journal of the Korean Gastric Cancer Association
2009;9(3):96-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Lymph node metastasis is an important factor in determining prognosis and therapeutic options for early gastric cancer (EGC) patients. Vascular endothelial growth factor (VEGF)-C and D are known as lymphangiogenic factors, and cyclooxygenase (COX)-2 is thought to play a role in lymph node metastasis in gastric carcinoma. This study was designed to determine whether the expression of VEGF-C, VEGF-D, and COX-2 is associated with clinicopathologic factors, especially lymph node metastasis in EGCs invading the submucosa. MATERIALS AND METHODS: Tissue samples were obtained from 85 Patients undergoing standard gastrectomy with lymph node dissection between 1991 and 2007 in the Department of Surgery of Daejeon St. Mary's Hospital in Daejeon, Korea. All patients were diagnosed with gastric cancers and submucosal invasion. We examined the expression of VEGF-C, VEGF-D, and COX-2 using immunohistochemical methods. RESULTS: Of the 85 patients, 16 (18.8%) had lymph node metastasis. VEGF-C, VEGF-D, and COX-2 were positively expressed in 34.1% (29/85), 22.3% (19/85), and 37.6% (32/85) of the patients. VEGF-C and COX-2 expression was significantly correlated with lymph node metastasis (P<0.05). A positive correlation existed between VEGF-C and COX-2 expression (P<0.001). CONCLUSION: VEGF-C and COX-2 expression is associated with lymph node metastasis in gastric cancer with submucosal invasion. VEGF-C and COX-2 may thus be predictive markers for lymph node metastasis in EGC patients with submucosal invasion.
