Effect observation of basal insulin combined with oral antidiabetic drugs in treating type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2015.07.040
- VernacularTitle:基础胰岛素联合口服降糖药治疗2型糖尿病的临床疗效观察
- Author:
Chunlai ZHOU
;
Xia QIU
;
Xu HE
- Publication Type:Journal Article
- Keywords:
premixed insulin;
basal Insulin;
insulin glargine;
Type 2 diabetes mellitus
- From:
International Journal of Laboratory Medicine
2015;(7):956-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effectiveness and safety of basal insulin plus oral antidiabetic drugs (OADs) in treating the patients with type 2 diabetic mellitus (T2DM ) ,who were poor blood sugar control by premixed insulin with or without OADs . Methods 32 cases of T2DM and poor blood sugar control by premixed insulin combinated with or without OADs stopped the premixed insulin therapy and changed to insulin glargine plus OADs for 16 weeks .Glycosylated haemoglobin (HbA1c) ,fasting blood glucose(FBG) ,postprandial blood glucose(PBG) ,body mass index (BMI) and mean daily insulin dose were compared among patients .And the episodes of hypoglycemia events were recorded .Results After 16‐week treatment ,HbA1c ,FBG ,PBG and BMI were all significantly decreased comapared with before treatment (P<0 .01) .The mean insulin glargine daily dose was significantly decreased compared with the premixed insulin dose at admission .2 cases (6% )appeared twice hypoglycemia episodes during the treatment period ,all were general hypoglycemia .Conclusion Basal insulin once daily can effectively improve the sugar metabolism in T2DM patients failed by premixed insulin with or without OADs ,moreover the body mass is not increased .
