Systemic lupus erythmatosus and panniculitis presenting as multiple ulcers:one case report
10.3969/j.issn.1671-167X.2015.02.033
- VernacularTitle:系统性红斑狼疮合并皮肤脂膜炎多发溃疡1例
- Author:
Yu WANG
;
Yanjie HAO
;
Juan ZHAO
;
Zhuoli ZHANG
- Publication Type:Journal Article
- Keywords:
Panniculitis,lupus erythematosus;
Lupus erythematosus,systemic;
Skin ulcers
- From:
Journal of Peking University(Health Sciences)
2015;(2):352-357
- CountryChina
- Language:Chinese
-
Abstract:
SUMMARY A 36-year-old woman had an 8-year history of systemic lupus erythematosus (SLE) and was being treated with 10 mg/d of prednisone.She presented with a 6-month history of intermittent fever and multiple painful multi skin erythematous macules in her button, hips and extremities that had slowly en-larged to 8 cm ×4 cm in diameter.The lesions started as painful erythematous macules, which eventually ulcerated and scared.Laboratory tests showed leukopenia, protenuria, positive anti-double strand DNA and hypocomplementemia.Cultures of the bottom ulcer were E.Coli, fugus and Tuberculous mycobacteria were both negative.Biopsy was performed and revealed necrosis of epidermis, thrombus and cellulose de-generation in epidermis with neutrophils karyorrhexis and vasculitis.Her SLE was active, so she was pre-scribed antibiotics for 2 weeks and prednisone was added to 60 mg/d for a month.However her skin ul-cers did not relieve.When prednisone was added to 120 mg/d with combination therapy of cyclophospha-mide and hydroxychloroquine, her skin ulcer cicatrized gradually.
