Analysis of serum homocysteine,folate acid and vitamin B12 levels in patients with cerebral infarction
10.3969/j.issn.1673-4130.2015.07.015
- VernacularTitle:脑梗死患者血清同型半胱氨酸、叶酸及维生素B 12水平的分析
- Author:
Shunjun LI
;
Hao WU
- Publication Type:Journal Article
- Keywords:
homocysteine;
folate acid;
vitamin B12;
cerebral infarction
- From:
International Journal of Laboratory Medicine
2015;(7):899-900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the serum levels of homocysteine (Hcy) ,folate acid (FA) and vita‐min B12 (VitB12 ) with cerebral infarction .Methods The enzymatic cycling method and chemiluminescence immunoassay were used to detect the serum Hcy ,FA and Vit B12 levels in 60 patients with cerebral infarction ,and then the detection results were compared the results of 40 people undergoing physical examination in the same period .Results The serum Hcy level in the cerebral infarction group was (23 .16 ± 8 .17)μmol/L ,which was significantly higher than (8 .09 ± 2 .45)μmol/L in the control group(P<0 .01) ,and the serum FA and Vit B12 levels in the cerebral infarction group were (6 .12 ± 2 .19) ng/mL and (323 .92 ± 133 .79)μmol/L ,which were in the control group lower than (10 .57 ± 5 .70) ng/mL and (530 .85 ± 168 .56)μmol/L in the control group (P<0 .01) .The serum Hcy level in the cerebral infarction group showed the negative correlation with FA and VitB 12 levels ( r1 = - 0 .444 , r2 = -0 .535 ,P<0 .05) .Conclusion High hyperhomocysteinemia is an independent risk factor of cerebral infarction and is related to the decrease of FA and VitB12 .
