Evaluation on diagnostic value of leucine aminopeptidase in hyperthyroidism
10.3969/j.issn.1673-4130.2015.07.038
- VernacularTitle:评价亮氨酸氨基肽酶在甲状腺功能亢进中的诊断价值
- Author:
Jing WANG
;
Zhifeng LI
;
Shouyang XIA
- Publication Type:Journal Article
- Keywords:
leucine aminopeptidase;
hyperthyroidism;
thyroid hormone
- From:
International Journal of Laboratory Medicine
2015;(7):952-953
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect serum leucine aminopeptidase (LAP) level in the patients with hyperthyroidism for investiga‐ting the changes of LAP in the patients with thyroid dysfunction and its clinical significance .Methods 117 patients with hyperthy‐roidism were taken as the test group and 109 healthy people as the control group .The differences of various laboratory indexes were comparatively analyzed and the correlation between LAP with FT 3 ,FT4 and TSH was analyzed .117 patients with hyperthyroidism were divided into the liver damage group(52 cases) and non‐liver damage group(65 cases) and performed the LAP determination . Results The serum LAP ,FT3 ,FT4 and TSH levels in the hyperthyroidism whole group ,hyperthyroidism liver damage group and hyperthyroidism non‐liver damage group had statistically significant differences compared with those in the control group (P<0 .01) ,serum LAP was positively correlated with FT 3 and FT4 ,and negatively correlated with TSH ;LAP ,FT3 ,FT4 and TSH had no statistical differences between the hyperthyroidism live damage group and the hyperthyroidism non‐liver damage group (P>0 .05) .Conclusion The serum LAP content is closely related with the thyroid hormones and has certain clinical reference value for the diagnosis ,disease condition evaluation and medication .Lap can serve as an independent diagnostic indicator .
