Gender Differences in Susceptibility to Smoking among Patients with Lung Cancer.
10.3904/kjim.2011.26.4.427
- Author:
Jeong Seon RYU
1
;
Sang Hoon JEON
;
Jung Soo KIM
;
Jung Hwan LEE
;
Seong Hyun KIM
;
Ji Taek HONG
;
Ju Hong JEONG
;
Ji Joong JEONG
;
Myung Dong LEE
;
Sang Joon MIN
;
Hae Seong NAM
;
Jae Hwa CHO
;
Seung Min KWAK
;
Hong Lyeol LEE
;
Hyun Jung KIM
Author Information
1. Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea. jsryu@inha.ac.kr
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Gender;
Lung neoplasms;
Smoking;
Disease susceptibility;
Pulmonary function
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Chi-Square Distribution;
Cohort Studies;
Female;
*Gender Identity;
Humans;
Korea/epidemiology;
Lung Neoplasms/complications/*epidemiology/pathology;
Lung Volume Measurements;
Male;
Middle Aged;
Respiratory Function Tests;
Risk Assessment;
Sex Factors;
Smoking/*adverse effects/epidemiology
- From:The Korean Journal of Internal Medicine
2011;26(4):427-431
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To determine whether female smokers are more or less susceptible to the detrimental pulmonary-function effects of smoking when compared to male smokers among patients with lung cancer. METHODS: Pack-years and pulmonary function indices were compared between 1,594 men and women with lung cancer ifferences in individual susceptibility to smoking were estimated using a susceptibility index formula. RESULTS: Of the patients, 959 (92.8%) men and 74 (7.2%) women were current smokers. Common histological types of lung cancer were squamous cell carcinoma, adenocarcinoma, and small cell carcinoma, among others. Women had a lower number of pack-years, forced expiratory volume in 1 second (FEV1, liters), forced vital capacity (FVC, liters), and total lung capacity (TLC, liters) compared to those of men (25.0 +/- 19.2 vs. 42.9 +/- 21.7 for pack-years; 1.4 +/- 0.5 vs. 2.0 +/- 0.6 for FEV1; 3.0 +/- 0.7 vs. 2.0 +/- 0.6 for FVC; 4.5 +/- 0.8 vs. 5.7 +/- 1.0 for TLC; all p < 0.001). The susceptibility index for women was significantly higher compared to that of men (1.1 +/- 4.1 vs. 0.7 +/- 1.1; p = 0.001). A significant inverse association was shown between the susceptibility index and TLC and FVC (r = -0.200 for TLC, -0.273 for FVC; all p < 0.001). CONCLUSIONS: The results suggest that the detrimental effects of smoking on pulmonary function are greater in women, as compared to those in men, among patients with lung cancer.
