CRRT at early stageon in patients with severe acute pancreatitis applied to preventing acute lung injury in patients with severe acute pancreatitis
10.3760/cma.j.issn.1008-6706.2015.07.005
- VernacularTitle:早期连续性肾替代治疗对重症急性胰腺炎患者急性肺损伤的影响
- Author:
Mindan XIE
;
Haili CHEN
;
Xiaoqin LIN
;
Jinbo ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Interleukin;
Tumor necrosis factor-α;
Continuous renal replacement therapy;
Oxy-genation index;
Acute lung injury/acute respiratory distress syndrome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(7):973-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of early continuous renal replacement thempy(CRRT)on acute lung injury and prognosis in severe acute pancreatitis (SAP)patients.Methods 46 SAP patients were divided into the two groups randomly:the control group and CRRT treatment group.The levels of IL-1β,IL-6,TNF-α,the APACHEⅡscore,oxygenation index,the incidence of acute lung injury(ALI)/acute respiratory distress syndrome (ARDS),ICU stay were compared between the two groups.Results The level of interleukin-6(IL-6)in the con-trol group was significantly higher than that in CRRT group in day 1(t=2.265,P<0.05);The levels of interleukin-1β(IL-1β),interleukin-6 (IL-6 ),tumor necrosis factor-α(TNF -α)in the control group were significantly higher than that in CRRT group in day 3(t=2.305,2.471,2.293,all P<0.05);the oxygenation index in the control group was significantly lower than that in CRRT group in day 3(t=2.386,P<0.05);the incidence of ALI/ARDS, the ICU stay days,the fatality rate in the control group were significantly higher than that in CRRT group(P<0.05);there was no significant differences between late group than that early group in gender,age,APACHE Ⅱ score (all P>0.05).Conclusion Early CRRT therapy can eliminate the IL-1β,IL-6 and TNF-αin SAP patients,which can improve the oxygenation index and reduce the incidences of ALI/ARDS,may provide more clinical benefits in the early phase of SAP.
