Effect and influence on lipid metabolism of ziprasidone combined with low dose of olanzapine in the treat-ment of schizophrenia with depressive symptoms
10.3760/cma.j.issn.1008-6706.2015.07.018
- VernacularTitle:齐拉西酮联合小剂量奥氮平治疗伴抑郁症状精神分裂症的疗效观察及对脂代谢的影响
- Author:
Wenliang SHAO
;
Wangqiang LYU
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Depressive symptoms;
Ziprasidone;
Olanzapine;
Lipid metabolism
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(7):1014-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of ziprasidone combined with low dose of olanzapine in the treat-ment of schizophrenia with depressive symptoms,and its lipid metabolism.Methods According to the digital table, 108 schizophrenia patients with depressive symptoms were randomly divided into the two groups.The treatment group (n=54)was given starting doses of ziprasidone with 2.5mg/d,increased to 5 -10 mg/d for 1 week.And starting doses of olanzapine with 40mg/d,increased to 120 -160mg/d for 2 weeks.The control group (n=54)was given starting doses of olanzapine with 5mg/d,increased to 10-20mg/d for 2 weeks.The treatment course was 8 weeks.The PANSS score and HAMD score,indicators of obesity and blood lipid and adverse effect were observed.Results The PANSS score and HAMD score in the treatment group[(40.19 ±9.23)vs (59.29 ±10.14)]and the control group [(8.58 ±3.16)vs (12.19 ±4.04)]were significantly lower than those before treatment(t=9.41,4.91,6.51, 5.20,all P<0.05),and the scores in the treatment group were reduced more remarkably(t=5.11,3.01,all P<0.05).The waistline(83.45 ±5.29)cm,BMI(26.95 ±2.53)kg/m2,WHR(23.76 ±2.55)cm in the control group were all increased compared with those before treatment(t=5.14,3.18,all P<0.05)while the indicators[(23.76 ± 2.55)vs (23.76 ±2.55)]above improved more remarkably in the treatment group than those in the control group (t=5.38,4.53,all P<0.05).Compared with before treatment,the level of TC (6.54 ±0.86)mmol/L,TG(2.26 ± 0.83)mmol/L,LDL-C(3.94 ±0.43)mmol/L were increased remarkably,and HDL-C(1.02 ±0.18)mmol/L was reduced in the control group,TC(5.35 ±0.58)mmol/L in treatment group in the treatment group (t=4.20,3.27, 3.91,2.97,4.47,all P<0.05),while the indicators of blood lipid in the treatment group were better than those in the control group (t=3.18,3.01,2.76,2.87,all P<0.05).The TESS score in the treatment group(3.35 ± 0.57)point was lower than that in the control group(4.93 ±1.03)point (t=3.98,P<0.05).Conclusion It is effective and safe of combined with low dose of olanzapine in the treatment of schizophrenia with depressive symp-toms,which can contribute to effectively alleviate symptoms of depression with low effect on body weight and blood lip-id metabolism,less adverse reaction.
