Roles of atypical chemokine receptors in progression and metastasis of tumor

VernacularTitle:非典型性趋化因子受体在肿瘤发展与转移中的作用
Author: Jian LUO ; Dongning LI ; Lu KONG ; Cong LI ; Pin LIANG
Publication Type:Journal Article
Keywords: Atypical chemokine receptors; Tumor; Metastasis
From: Chinese Journal of Pathophysiology 2015;33(4):764-768
CountryChina
Language:Chinese
Abstract: [ ABSTRACT] Chemokines and their receptors have been implicated mostly in tumor progression and metastasis. Atypical chemokine receptors ( ACKRs) comprise a group of 7-transmembrane domain proteins structurally similar to G pro-tein-coupled receptors.However, ACKRs do not induce classical signaling via the typical G protein-mediated pathways. ACKRs efficiently internalize the cognate chemokine ligands and act as scavengers instead.ACJRs are composed of at least 3 members of chemokine receptors: Duffy antigen receptor for chemokines ( DARC, also known as ACKR1 ) , D6 ( also known as ACKR2) and ChemoCentryx chemokine receptor (CCX-CKR, also known as ACKR4).These receptors bind to and/or internalize their chemoattractant ligands without activating signal transduction cascades leading to cell migration.In this review, we summarize the recent progress regarding the roles of ACKRs in the progression and metastasis of tumor.