An Adult Case of Chronic Active Epstein-Barr Virus Infection with Interstitial Pneumonitis.
10.3904/kjim.2011.26.4.466
- Author:
Eun Jeong JOO
1
;
Young Eun HA
;
Dong Sik JUNG
;
Hae Suk CHEONG
;
Yu Mi WI
;
Jae Hoon SONG
;
Kyong Ran PECK
Author Information
1. Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. krpeck@skku.edu
- Publication Type:Case Reports
- Keywords:
Epstein-Barr virus infection;
Immunocompetence;
Lung diseases;
Interstitial pneumonitis
- MeSH:
Adult;
Chronic Disease;
Epstein-Barr Virus Infections/complications/*pathology/radiography;
Female;
*Herpesvirus 4, Human;
Humans;
Immunocompetence;
Lung Diseases/etiology/pathology;
Lung Diseases, Interstitial/etiology/*pathology/radiography
- From:The Korean Journal of Internal Medicine
2011;26(4):466-469
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic active Epstein-Barr virus (CAEBV) infection is characterized by persistent infectious mononucleosis-like symptoms, an unusual pattern of Epstein-Barr virus (EBV) antibodies, detection of the EBV genome in affected tissues or peripheral blood, and chronic illness that cannot be attributed to any other known disease. This is the first reported Korean case of an immunocompetent adult with CAEBV-associated interstitial pneumonitis. A 28-year-old female was admitted with a fever that persisted for 3 weeks. She had multiple lymphadenopathy, hepatosplenomegaly, pancytopenia, and elevated serum aminotransferase levels. Serology for antibodies was positive and chest computed tomography showed diffuse ground glass opacities in both lungs. Histopathology of the lung tissue showed lymphocyte infiltration, and EBV DNA was detected in those lymphocytes using in situ hybridization with an EBV-encoded RNA probe. After 1 month of hospitalization, she improved without specific treatment.
