The effects of Telbivudine for the prevention of perinatal transmission of hepatitis B virus infection from pregnant women to newborn on the expression of IL-17A,IL-10,IL-6 in the maternal plasma,umbilical plasma,neonatal plasma
10.3760/cma.j.issn.1008-6706.2015.05.021
- VernacularTitle:替比夫定阻断乙型肝炎病毒母婴垂直传播对孕妇、脐带以及新生儿血浆白介素－17A、－10、－6的影响
- Author:
Chunxiang XU
;
Huili LIANG
;
Jingfang REN
;
Lili LIU
;
Wei ZHAO
;
Mei WANG
- Publication Type:Journal Article
- Keywords:
Hepatitis Brirus;
Interleukins;
Telbivudine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(5):702-704
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of interleukin -17A(IL-17A),interleukin-10(IL-10), interleukin-6 ( IL-6 ) in the maternal plasma , umbilical plasma , neonatal plasma from the pregnant women who accepted the Telbivudine for the prevention of perinatal transmission of hepatitis B virus infection .Methods 85 preg-nant women who were delivered in the hospital were chosen [ Telbivudine group 25 cases,HBVDNA high viral level group,HBVDNA negative group,non-infection group(health pregnant),each group included 20 cases].The level of the serum of IL-17A,IL-10,IL-6 in the maternal plasma,umbilical plasma,neonatal plasma from the different group was prospectively analyzed by the CBA method .Results The levels of IL-17A in the maternal plasma,um-bilical plasma,neonatal plasma of the Telbivudine group [(15.29 ±4.80)pg/mL,(19.45 ±4.80)pg/mL,(17.32 ± 4.18)pg/mL]were lower than the HBVDNA high viral level group [(26.03 ±4.88)pg/mL,(34.07 ±5.59)pg/mL, (24.12 ±4.76)pg/mL],there were significant differences(P=0.000,0.001,0.019);The level of IL -10 in the maternal plasma,umbilical plasma,neonatal plasma of the Telbivudine group [(6.08 ±1.32) pg/mL,(2.33 ± 0.68)pg/mL,(3.74 ±0.61)pg/mL]were higher than the HBVDNA high viral level group [(3.95 ±1.21)pg/mL, (1.71 ±0.53)pg/mL,(2.22 ±0.55)pg/mL],there were significant differences(P=0.023,0.015,0.012);The level of IL-6 in the maternal plasma ,umbilical plasma ,neonatal plasma of the Telbivudine group were lower than the HBVDNA high viral level group,there were significant differences (all P <0.05).Conclusion Telbivudine can cause the inhibition of the replication of HBV virus , partially reverse the immunologic dissonance of the pregnant women with HBV virus ,which is conducive to maintaining pregnancy .
