The curative effect observation of combined octreotide and omeprazole for the treatment of esophageal variceal bleeding
10.3760/cma.j.issn.1008-6706.2015.05.026
- VernacularTitle:奥曲肽联合奥美拉唑治疗食管胃底静脉曲张破裂出血疗效观察
- Author:
Xiaoqing WU
- Publication Type:Journal Article
- Keywords:
Esophageal and gastric varices;
Octreotide;
Omeprazole
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(5):717-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of combined octreotide and omeprazole for the treatment of bleeding of esophageal and gastric varices(BEV),analyze its security and provide objective basis for clinical treatment.
Methods 92 patients with BEV were randomly selected .According to the treatment methods , they were randomly divided into the control group and observation group .45 cases in the control group were treated with octreotide ,47 cases in observation group were treated with omeprazole on the basis of the control group .The main indexes were the treatment effect,48h rebleeding rate,bleeding time and volume of blood transfusion and adverse reaction .Results The total effective rate of the observation group was 93.62%,more than that of control group 82.22%,the difference was statistically significant(χ2 =6.24,P<0.05).The effective rate of the observation group was 6.38%,lower than that of the control group 17.78%,the difference was statistically significant (χ2 =6.17,P<0.05).The bleeding time of the observation group was (30.41 ±1.82) h,less than that of the control group (41.83 ±2.69) h,the difference was statistically significant (t =9.47,P <0.05).The blood transfusion of the observation group was (374.16 ± 28.30)mL,less than the control group(582.33 ±36.19)mL,the difference was statistically significant (t=12.31, P<0.05).48h the rebleeding rate of the observation group was 6.38%,lower than that of the control group 20.00%,the difference was statistically significant (χ2 =5.90,P<0.05).The adverse reactions of two groups had no significant difference(χ2 =2.78,P>0.05).Conclusion There is the better for clinical effect of combined octreoti-de and omeprazole for the treatment of BEV , which could reduce the rebleeding rate , shorten the bleeding time , decrease the volume of blood transfusion ,and there was no obvious adverse reactions .
