Research Advances in G Protein Coupled Receptor-mediated Electroacupuncture Intervention in Rheumatoid Arthritis Pain
10.13460/j.issn.1005-0957.2015.03.0273
- VernacularTitle:G蛋白偶联受体介导电针干预类风湿关节炎炎性疼痛研究进展
- Author:
Jun ZHU
;
Yin ZHOU
;
Yunfei CHEN
- Publication Type:Journal Article
- Keywords:
Acupuncture therapy;
Arthritis,rheumatoid;
Inflammatory pain;
G protein coupled receptors
- From:
Shanghai Journal of Acupuncture and Moxibustion
2015;(3):273-276
- CountryChina
- Language:Chinese
-
Abstract:
G protein coupled receptors (GPCRs) have a marked mediating effect on bodily immunoregulation. Recent years’ studies found that GPCRs plays an important role in the mechanism of the intervening effect of electroacupuncture on rheumatoid arthritis pain. Of them, adrenergic receptors, 5-hydroxytryptamine receptors, adenosine receptors, opioid peptide receptors, dopamine receptors and cannabinoid receptors separately mediate the effect of electroacupuncture on rheumatoid arthritis pain in the central and peripheral nervous systems and the inflammatory region. The exploration of the mechanism by which electroacupuncture increases GPCRs expression is our future research direction.
