Protective effect of GuanXinShiWeiWan on isolated rat hearts with ischemia reperfusion injury
- VernacularTitle:冠心十味丸对离体大鼠心肌缺血再灌注损伤后的保护作用
- Author:
Lijuan LIU
;
Lei FAN
;
Fuhou CHANG
;
Tuya BAI
;
Xiaoli LV
;
Lin LI
- Publication Type:Journal Article
- Keywords:
GuanXinShiWeiWan;
myocardial ischemia reperfusion injury;
cardiac enzyme
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of GuanXinShiWeiWan on ischemia reperfusion(I-R) injury rat.Methods 50 Wistar rats were randomly divided into normal group, model group, GuanXinShiWeiWan low ( 0.3 mg/kg ) and high ( 0.9 mg/kg ) dose group and positive group, each had 10 rats.Adopting the model of ischemia reperfusion injury of isolated rat hearts, the contents of SOD,MDA,LDH,CK and Ca2 +-ATP, Ca2 +-Mg2 +-ATP, Na +-K +-ATP in cardiac muscle tissue were tested and compared.Results Compared with model group, GuanXinShiWeiWan significantly improved the activities of SOD、Ca2 +-ATP,Ca2 +-Mg2 +-ATP and Na +-K +-ATP (P<0.05 or P<0.01) in cardiac muscle tissue which injured by ischemia reperfusion, while reducing markedly the contents of MDA,LDH,CK(P<0.05 or P<0.01).Conclusion GuanXinShiWeiWan can profect the cardiac muscle of ischemia reperfusion.
