A meta-analysis of effects ofLanqin oral liquid and ribavirin on in fantile hand-foot- mouth disease
10.3760/cma.j.issn.1673-4246.2015.04.018
- VernacularTitle:蓝芩口服液联合利巴韦林治疗小儿手足口病的meta分析
- Author:
Ning SHI
;
Hongju GUO
;
Yanlei LI
;
Minxiang PAN
;
Xiaoxian BAI
;
Lirong CHANG
- Publication Type:Journal Article
- Keywords:
Lanqin oral liquid;
Ribavirin;
Infantile hand-foot-mouth disease;
Randomized controlled trial;
Meta-analysis
- From:
International Journal of Traditional Chinese Medicine
2015;(4):357-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the clinical efficacy of Lanqin Oral Liquid(LOL)and ribavirin on infantile hand-foot-mouth disease(HFMD).Methods The randomized controlled trials(RCT)of LOL and ribavirincombined for treating HFMD were retrieved from EMbase, PubMed, CNKI, CBM and VIP(from establish to Oct 2014), the methodological quality of included literature was evaluated, and data analyses were performed with RevMan 5.2 software.Results Fifteen studies involving 2 016 patients were ultimately identified.The meta-analysis results showed that the effective rate of LOL group was superior to that of the control,OR(95%CI)was 5.80 (3.94, 8.52), and there were significant differences in the antifebrile time, erythra regression time, herpes regression time and oral ulcer regression time between the groups,MD (95%CI): -1.29 (-1.45,-1.13), -1.88 (-2.44,-1.33), -1.57 (-2.36,-0.78), -1.57 (-2.07,-1.08), respectively. Conclusion Based on the present clinical evidence, the meta-analysis results indicate that LOL and ribavirin treating HFMD is effective and safe. However, due to the uneven quality of these included studies, this conclusion need more large sample size and high-quality clinical RCTs to be confirmed.
