Correlation Between Apparent Diffusion Coefifcient Value on MR Diffusion-weighted Imaging and Prognostic Factors in Breast Invasive Ductal Carcinomas
10.3969/j.issn.1005-5185.2015.03.007
- VernacularTitle:乳腺浸润性导管癌磁共振扩散加权成像表观扩散系数与预后因子表达的关联性分析
- Author:
Zongyu XIE
;
Liuquan CHENG
;
Zhen YANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,ductal,breast;
Diffusion magnetic resonance imaging;
Diffusion weighted imaging;
Apparent diffusion coefficient;
Prognosis;
Ki-67 antigen;
DNA topoisomerases,type II
- From:
Chinese Journal of Medical Imaging
2015;(3):183-187
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo explore the correlation between apparent diffusion coefficient (ADC) value on MR diffusion-weighted imaging (DWI) and prognostic factors in breast invasive ductal carcinomas.Materials and Methods 103 patients with pathology-proven invasive breast ductal carcinomas underwent DWI MR scan using b=1000 s/mm2. The minimum ADC values of the lesions were determined. Histopathological specimens were analyzed for tumor size, lymph node metastasis, pathological grade (traditional prognostic factors) and the expression of prognostic factors including Ki-67, ToPo-IIα, P53 and CyclinD1. The correlations between ADC values and these prognostic factors were evaluated.Results In 103 breast invasive ductal carcinomas, there was no significant relationship between tumor size, lymph node metastasis, pathological grade and mean ADC values (P>0.05). The correlations between mean ADC values and the biological prognostic factors were not significant (P>0.05). However, positive correlations were observed between pathological grade and the expression of Ki-67 as well as ToPo-IIα(P<0.05).Conclusion ADC values cannot serve as a prognostic factor for invasive ductal breast carcinomas. However, the expression of Ki-67 and ToPo-IIα in breast invasive ductal carcinomas may be important in evaluating prognosis of the tumor and guiding clinical therapy.
