Hypersensitive c-reactive protein in combination with N-terminal brain natriuretic peptide precursor in the analysis of application of heart failure
10.3969/j.issn.1673-4130.2015.14.018
- VernacularTitle:超敏C反应蛋白联合 N-端脑利钠肽前体在心力衰竭中的应用分析
- Author:
Feng CAO
- Publication Type:Journal Article
- Keywords:
heart failure;
hypersensitive c-reactive protein;
N-terminal brain natriuretic peptide precursor;
diagnosis
- From:
International Journal of Laboratory Medicine
2015;(14):1996-1997
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the hypersensitive c‐reactive protein(hs‐CRP) combined N‐brain natriuretic peptide precursor application value in heart failure .Methods 50 cases of heart failure patients of our hospital as research object ,this group of patients as experimental group .In order to make the research more persuasive ,in addition to select 50 cases of healthy people as control group .Experimental group patients to standards as set by the u .s .New York heart association ,according to the grouping of 24 pa‐tients with rank Ⅱ ,Ⅲ level 15 patients ,11 patients with Ⅳ level .Using colloidal gold method of N‐terminal patients plasma brain natriuretic peptide precursor concentration and left ventricular ejection fraction ,the concentrations of plasma brain natriuretic pep‐tide precursor N‐end needs were determined and the concentration of the hospital for five days prior to admission .Measurement by scattering turbidimetry ,and also need the hs‐CRP serum levels .Results Compare two groups of measuring results were found that the experimental group than the control group of N‐the brain natriuretic peptide precursor level obviously higher ,and the left ven‐tricular ejection fraction was lower than the control group .For the hs‐CRP serum levels of the experimental group is significantly higher than the control group ,cardiac function classification as the increasing of the number of this gap is widening .At levels Ⅱ -Ⅳ obvious the differences between the three ,with statistical significance(P<0 .05) .Conclusion hs‐CRP and N‐brain natriuretic peptide precursor concentration can be as an important indicator of heart failure determination ,has united both in clinical can more effectively to diagnosis heart failure .hs‐CRP in combination with N‐terminal brain natriuretic peptide precursor obvious effects of application in heart failure ,is worth popularizing in clinical use .
