Combined detection of cerebrospinal fluid in diagnosis of intracranial infection
10.3969/j.issn.1673-4130.2015.14.033
- VernacularTitle:脑脊液联合检测在颅内感染诊断中的应用
- Author:
Dafu CHEN
;
Xiao SHAO
- Publication Type:Journal Article
- Keywords:
etiology;
biomarker;
intracranial infection;
early diagnosis
- From:
International Journal of Laboratory Medicine
2015;(14):2027-2028
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application of pathogenic examination and biomarkers detection of cerebrospinal fluid in diagnosis of intracranial infection .Methods Pathogenic and biomarkers examination were performed in cerebrospinal fluid of 49 cases with intracranial infection (infection group) and 49 cases of craniocerebral trauma but without intracranial infection (control group) .Results Adenosine deaminase activity obviously increased in tuberculous meningitis cases ,glucose levels decreased in bac‐terial meningitis and cryptococcal meningitis cases ,protein and IgA content increased in bacterial meningitis cases ,IgG levels in‐creased in bacterial meningitis and tuberculous meningitis cases ,IgM levels increased in tuberculous meningitis cases (P<0 .05) . There were no significant differences of biomarkers levels between viral meningitis cases and control group (P>0 .05) .Conclusion Combined pathogenic detection and biomarker detection of cerebrospinal fluid could be helpful for the diagnosis and treatment of intracranial infection .
