the Value of serum cystatin C and Homocysteine in different stage of renal damage in type 2 diabetes

VernacularTitle:血清 AAG和 Hcy与2型糖尿病肾病的关系
Author: Jinchang LIU ; Guixiong SHI ; Guijun YU ; Yuhong LI
Publication Type:Journal Article
Keywords: α1 acid glycoprotein; Homocysteine; type 2 diabetes
From: International Journal of Laboratory Medicine 2015;(14):2043-2044
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of serum α1 acid glycoprotein(AAG) and Homocysteine(Hcy) in different stage of renal damage in type 2 diabetes(T2DM ) .Methods a total of 128 patients with T2DM were recruited from January 2013 to Octo‐ber 2013 ,According to 24 h urinary albumin excretion rate (UAER) were divided into the first group ,the second and third groups , and choose 80 healthy cases over the same period as the normal control group .Serum AAG ,Hcy ,creatinine (Cr) and blood urea ni‐trogen (BUN) were detected ,the test results were analyzed statistically .Results There were significant differences in type 2 diabe‐tes mellitus group ,early diabetic nephropathy group ,clinical diabetic nephropathy group of the serum AAG ,Hcy levels(P<0 .05) , there were positively correlated (r=0 .673 ,P<0 .05) between UAER and serum AAG levels ,and were positively correlated (r=0 .35 ,P<0 .05) between UAER and Hcy levels .Conclusion Combined detection of serum AAG ,Hcy have a significant for early diagnosis of diabetic nephropathy and assessing the degree of renal injury in diabetes .