Research on the detection rate of couples at high risk of bearing babies with severe thalassemia among the people at reproductive age in foshan city,Guangdong province
10.3969/j.issn.1673-4130.2015.14.056
- VernacularTitle:佛山市育龄人群中生育严重珠蛋白生成障碍性贫血儿高风险夫妇检出率研究
- Author:
Haiying ZHANG
;
Guoxian LIU
- Publication Type:Journal Article
- Keywords:
thalassemia;
birth defect;
genotype;
occurrence rate
- From:
International Journal of Laboratory Medicine
2015;(14):2079-2080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the detection rate of couples at high risk of bearing babies with severe thalassemia and the occurrence rate of birth defect caused by severe thalassemia among the people at reproductive age in Foshan city ,Guangdong prov‐ince .Methods Peripheral blood samples were collected from 17 522 preparing pregnant couples of child bearing age .Mean corpus‐cular volume (MCV) <80 fL was used as the positive indication for screening thalassemia .And 348 positive samples were detected by molecular biological technique for further analysis .Statistical analysis was conducted based on the couple′s genetic test results . Results Among the people at reproductive age ,the detection rates of couples bearing babies with Hb Bart′s Hydrops Fetalis ,He‐moglobin H disease andβ‐thalassemia were 0 .36% ,0 .47% and 0 .20% respectively ,the total was 1 .03% .The occurrence rates of birth defect caused by the above severe thalassemia were 9 .0/10 thousand ,11 .8/10 thousand and 5 .0/10 thousand ,the total was 25 .8/10 thousand .Conclusion This research illustrated the degree of damage of birth defect caused by severe thalassemia among the people at reproductive age ,which could provide valuable fundamental materials for the launch of eugenic work in this region .
