Clinical Study ofYiqi Huatan Granules Combined with Carbocisteine to Reduce Acute Exacerbation of Chronic Obstructive Pulmonary Disease
10.3969/j.issn.1005-5304.2015.08.012
- VernacularTitle:益气化痰颗粒联合羧甲司坦减少慢性阻塞性肺疾病急性加重临床研究
- Author:
Feng GAO
;
Wei WU
;
Bin WANG
;
Wei WANG
;
Lichun ZHANG
;
Shan LI
- Publication Type:Journal Article
- Keywords:
Yiqi Huatan Granules;
chronic obstructive pulmonary disease;
acute exacerbation;
integration of traditional Chinese medicine and Western medicine
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;22(8):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety ofYiqi Huatan Granules combined with carbocisteine to reduce the acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Totally 108 patients in the stationary phase of COPD with qi deficiency or merging phlegm blockage/blood stasis syndrome were randomly divided into two groups. Patients in the control group were treated with carbocisteine and inhaled bronchodilators on-demand, while patients in the treatment group were treated withYiqi Huatan Granules combined with carbocisteine and bronchodilators for 24 weeks. Times and severity of acute exacerbations of COPD, TCM syndrome scores, lung function, and 6-minute walking distances of the two groups during the treatment period were observed.Results The average times of acute exacerbations of COPD in the treatment group (0.33 ± 0.55) were fewer than the control group (0.62 ± 0.71);the average times of severe acute exacerbations of COPD in the treatment group (0.12 ± 0.33) were fewer than the control group (0.28 ± 0.45), with statistical significance (P<0.05). Comparison between the TCM syndrome scores before and after treatment, TCM total syndrome scores, breathless/dyspnea score, breath shortness and fatigue score, and 6-minute walking distance in the treatment group were better than the control group (P<0.05), with better safety.Conclusion The treatment ofYiqi Huatan Granules combined with carbocisteine for COPD patients can effectively decrease times and severity of acute exacerbations of COPD, and improve TCM syndrome scores and 6-minute walking distance.
